Health Encyclopedia

Idiopathic autoimmune hemolytic anemia

Definition

Idiopathic autoimmune hemolytic anemia is a drop in the number of red blood cells due to a problem with the body's defense (immune) system.

Alternative Names

Autoimmune hemolytic anemia; Anemia - idiopathic autoimmune hemolytic

Causes, incidence, and risk factors

Idiopathic autoimmune hemolytic anemia is an acquired disease that occurs when antibodies form against a person's own red blood cells. In the idiopathic form of this disease, the cause is unknown.

There are other types of immune hemolytic anemias where the cause may result from an underlying disease or medication. Idiopathic autoimmune hemolytic anemia accounts for one-half of all immune hemolytic anemias. The onset of the disease may be quite rapid and very serious.

Risk factors are not known.

Symptoms

Signs and tests

Positive direct Coombs' test
Indirect Coombs' test
Elevated bilirubin levels
Low serum haptoglobin
Hemoglobin in the urine
Elevated reticulocyte count
Low red blood cell count and low serum hemoglobin

Treatment

The first therapy tried is usually treatment with prednisone. If prednisone does not improve the condition, a splenectomy (removal of the spleen) may be considered.

Immunosuppressive therapy is given if the person does not respond to prednisone and splenectomy. Imuran and Cytoxan have both been used.

Blood transfusions are given with caution, if indicated for severe anemia, because of the potential that blood may not be compatible and may bring on a reaction.

Expectations (prognosis)

Adults may have chronic, relapsing disease, but in children the anemia is usually short-lived.

Complications

Infection (from treatment)
Severe anemia

Calling your health care provider

Call your health care provider if you notice symptoms of anemia.

Prevention

There is no known prevention for idiopathic autoimmune hemolytic anemia, because the cause is unknown.

Review Date:2/6/2007
Reviewed By:William Matsui, MD, Assistant Professor of Oncology, Division of Hematologic Malignancies, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD. Review provided by VeriMed Healthcare Network.

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